Everything about The Taxane totally explained
The
taxanes are
diterpenes produced by the plants of the genus
Taxus (yews). As their name suggests, they were first derived from natural sources, but some have been synthesized artificially. Taxanes include
paclitaxel and
docetaxel. Paclitaxel was originally derived from the
Pacific yew tree.
Taxanes have been used to produce various
chemotherapy drugs. The principal mechanism of the taxane class of drugs is the disruption of
microtubule function. It does this by stabilizing
GDP-bound
tubulin in the microtubule. Microtubules are essential to cell division, and taxanes therefore stop this - a "frozen
mitosis". Thus, taxanes are essentially
mitotic inhibitors. In contrast to the taxanes, the
vinca alkaloids destroy
mitotic spindles. Both, taxanes and vinca alkaloids are therefore named
spindle poisons or mitosis poisons, but they act in different ways. Taxanes are also thought to be
radiosensitizing.
Further Information
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